WAS looks severely overmatched in this game, especially since it is dealing with a slew of injuries at key positions. SEA is getting stronger with the return of Sam Darnold and Nick Emmanwori.

Pass protection for Maye has been an issue which is not likely to improve with the starting RG out. JAX’s interior O-line is also its weak point, which NE will attack with simulated pressure. We expect a defensive battle decided by a FG or less.

With so many key injuries to both teams and Michael Penix playing in his first game back from ACL surgery, we think this will be an ugly, low-scoring game. GB’s D will likely stack the box and force Penix to make plays, while ATL’s pass rush will test the Packers’ weakened O-line.

The Saints’ competitiveness in this game depends on maintaining gap discipline and second-level execution to neutralize Henry. A healthy Olave provides Shough with the necessary leverage to sustain drives through the air, but we expect BAL to win this one comfortably at home.

IND must establish the run early to alleviate pressure on Jones, otherwise it will be a long night for the offense vs. Spagnuolo's schemes. We expect KC to deliver a more balanced attack and score more points than they did in the week 12 matchup last year due to the addition of Walker.

This matchup has all the makings of a lopsided blowout if MIA fails to establish the run and contain SF's explosive offense in the first half. The Dolphins' young roster simply isn't equipped to mount a comeback against an elite powerhouse on the road.

Everything in our analysis points to this game being a shootout. Neither team is strong defensively but both have high-powered offenses. Click through to see our 4 picks.

DEN will be able to move the ball through the air against an overhauled Chiefs secondary, but TDs may still be hard to come by. Walker will take some of the pressure off of Mahomes, but with their LT out, big plays and scoring will be limited.

With Tunsil out, limited weapons on offense, and a new offensive system, WAS will have difficulty moving the ball, but Daniels will make some plays. PHI lost AJ Brown and is also learning a new offense, but WAS D is bottom tier, so they should be able to score, led by a heavy dose of Barkley.

With all the question marks on offense for CLE, we think they will have trouble scoring TDs. JAX should be able to move the ball through the air against CLE D that is learning a new system with a first-time defensive play-caller. Expect CLE's D to get tired in 4th qtr, allowing JAX to score late.